منابع مشابه
Therapeutic orphans: European perspective.
There are several factors to be considered when facing the problem of therapeutic orphans. First, there is the scientific one. We are all convinced that there is much need for more data concerning the use of drugs in children, infants, and neonates. Second, there is a regulatory factor involving political and technical institutions. Finally, we have to consider the economic interest of the phar...
متن کاملEditorial Comment: Therapeutic Orphans
By an odd and unfortunate twist of fate, infants and children are becoming “therapeutic or pharmaceutical orphans.”1 Since 1962 they have been denied the use of many new drugs. The Drug Laws of 1962 had their inception following a pediatric tragedy—the thalidomide catastrophe. The laws of 1938 followed another which resulted from the use of a pediatric dosage form, “elixir” of sulfanilamide. By...
متن کاملDosing information for paediatric patients: are they really "therapeutic orphans"?
OBJECTIVES To review the approved product information (PI) of prescription medicines to determine the extent and nature of information available on paediatric dosing and the availability of paediatric dosage formulations in Australia. METHODS The PIs for all prescription medicines listed in the Australian Monthly Index of Medical Specialties (MIMS) were reviewed. Dosing information for each P...
متن کاملNuclear Receptors: Lonesome orphans
Nuclear receptors typically bind to DNA as homodimers or heterodimers, but increasing numbers of orphan receptors have been identified that bind DNA as monomers.
متن کاملOrphans in Africa
“In at least one important dimension — school enrollment — orphans are signifi cantly disadvantaged... Although poorer children in Africa are less likely to attend school, the lower enrollment of orphans is not accounted for solely by their lower wealth. Instead, our results suggest that the special disadvantage orphans face is primarily due to their living arrangements. Across a large number o...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 1970
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/121.3.348